NF-kB and cytokines in pancreatic acinar cells

NF-kappaB and cytokines in pancreatic acinar cells.

Reactive oxygen species (ROS), generated by infiltrating neutrophils, are considered as an important regulator in the pathogenesis and deveolpment of pancreatitis. A hallmark of the inflammatory response is the induction of cytokine gene expression, which may be regulated by oxidant-sensitive transcription factor, nuclear factor-kappaB (NF-KB). Present study aims to investigate whether neutroph...

CCK independently activates intracellular trypsinogen and NF-kB in rat pancreatic acinar cells

Han, Bing, Baoan Ji, and Craig D. Logsdon. CCK independently activates intracellular trypsinogen and NF-kB in rat pancreatic acinar cells. Am J Physiol Cell Physiol 49: C465–C472, 2001.—In the cholecystokinin (CCK) hyperstimulation model of acute pancreatitis, two early intracellular events, activation of trypsinogen and activation of nuclear factor-kB (NF-kB), are thought to be important in th...

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs

In response to inflammation, pancreatic acinar cells can undergo acinar-to-ductal metaplasia (ADM), a reprogramming event that induces transdifferentiation to a ductlike phenotype and, in the context of additional oncogenic stimulation, contributes to development of pancreatic cancer. The signaling mechanisms underlying pancreatitis-inducing ADM are largely undefined. Our results provide eviden...

Pancreatic Acinar Cells

Trisphosphate in Pancreatic Acinar Cells

The mechanisms of agonist-induced Ca 2 1 spikes have been investigated using a caged inositol 1,4,5-trisphosphate (IP 3 ) and a low-affinity Ca 2 1 indicator, BTC, in pancreatic acinar cells. Rapid photolysis of caged IP 3 was able to reproduce acetylcholine (ACh)induced three forms of Ca 2 1 spikes: local Ca 2 1 spikes and submicromolar ( , 1 m M) and micromolar (1–15 m M) global Ca 2 1 spikes...